First Dose is the opening story strand of the Los Santos Drug Wars update. Dax, the head of the Fooliganz crew, runs a drug-fueled hideout called The Freakshop in Mirror Park, and he wants help against the Lost MC and a few other rivals. There are 6 jobs, and each one takes 1 to 4 players.
How to start
Ron phones you to start the strand and asks you to meet him at Ace Liquor in Sandy Shores, where Welcome to the Troupe begins. Finishing it adds The Freakshop and Dax as a contact. After that each job opens when you finish the one before it, and Dax calls or texts you with the next invitation. Play them in the order below, because later jobs depend on what happened earlier. Once you finish the strand you can replay any job from the Pause Menu job list. When First Dose is done, the story continues with Last Dose.
Payouts are not fixed. Each job pays a maximum for a quick finish and less the longer you take, and the reward also depends on the current update, so check the table in-game rather than relying on a figure from memory. For the general rules see payouts and RP.
| Mission | Contact | Rank | Players | Top payout | RP |
|---|---|---|---|---|---|
| First Dose 1 – Welcome to the Troupe |  Dax | 1 | 1 to 4 | – | – |
| First Dose 2 – Designated Driver | Dax | 1 | 1 to 4 | – | – |
| First Dose 3 – Fatal Incursion | Dax | 1 | 1 to 4 | – | – |
| First Dose 4 – Uncontrolled Substance | Dax | 1 | 1 to 4 | – | – |
| First Dose 5 – Make War not Love | Dax | 1 | 1 to 4 | – | – |
| First Dose 6 – Off the Rails | Dax | 1 | 1 to 4 | – | – |
Story order
Welcome to the Troupe is a defense job. You hold the liquor store while Lost MC bikers attack from every side, then recover Dax’s stolen RV from a fishery and drive him to his new hideout. Designated Driver has you collect a trailer of party supplies, survive an ambush on the way back, and then break into the Lost MC clubhouse to photograph their plans and take their weed.
Fatal Incursion is a night job. You wreck the Lost MC’s stock at Stab City, clear meth packages out of Millar’s Fishery, then steal a seaplane and fly it to the storm drain beside the Freakshop. Uncontrolled Substance is the oddest of the set: a party that turns into a hallucination, where you ride a BMX through tunnels and hunt rabbits. There is little real danger, so just keep moving.
Make War not Love sends you into the desert to wreck a hippy lab camp, blow up delivery vans and finish at the Altruist Camp in the mountains. Off the Rails is the closing job, with a sneak-in at Humane Labs and then a chase after a runaway train.
Tips for these jobs
Bring body armor and a rifle or SMG with a big magazine, since the first job is fought in waves. Make War not Love covers a lot of ground, so use a fast car with some ground clearance. In Off the Rails, stay close to the tracks and keep your speed up so you catch the train before it gets away.
