Claude has one safehouse on each island. Walk into the doorway to save the game, which also moves the clock forward six hours. Each safehouse has a garage beside it, and any car parked inside when you save stays there for good. Saving is only possible when you are not on a mission.
| Safehouse | Where | Garage | Opens after |
|---|---|---|---|
| Portland | A back street in the Red Light District, close to Luigi’s club | 1 car | Give Me Liberty |
| Staunton Island | A warehouse at the edge of Belleville Park | Several cars | Last Requests |
| Shoreside Vale | The tower blocks in Wichita Gardens | Several cars | A Drop in the Ocean |
Portland safehouse
8-Ball leads you to this run-down building in the Red Light District in the first mission, Give Me Liberty. The help text explains saving and the garage next door. It is the smallest garage in the game, holding only one car.
Staunton Island safehouse
Asuka gives you this warehouse at the edge of Belleville Park in Last Requests. Its garage holds more cars, which makes it the best place to keep the bulletproof Patriot from Marked Man and the cars you collect for Import/Export.
Shoreside Vale safehouse
An apartment in the Wichita Gardens tower blocks, given after A Drop in the Ocean. D-Ice’s payphone and the Rumpo Rampage van are both close by.
Pickups outside the safehouses
Many 100% tasks put rewards outside every safehouse. Each one respawns after you take it, so a safehouse becomes a free armory.
| Pickup | Earned by |
|---|---|
| Pistol, Uzi, Grenades, Shotgun, Body Armor, Molotovs, AK-47, Sniper Rifle, M16, Rocket Launcher | Every 10 hidden packages, one item each |
| Health | Paramedic level 8, or 43 patients rescued |
 Adrenaline | 78 patients rescued in Paramedic |
 Police bribes, up to six | Every 10 criminals killed per island in Vigilante |
 Flamethrower | 20 fires on each island in Firefighter |